2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101700A
    LCB 2853 sodium
    		Antagonist
    LCB 2853 sodium is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist. LCB 2853 sodium exhibits anti-aggregant and anti-vasospastic effects. LCB 2853 sodium can be used for the research of cardiovascular disease, such as hypertension.
    LCB 2853 sodium
  • HY-157495
    EP3 antagonist 6
    		Antagonist
    EP3 antagonist 6 (compound 5) is a potent, orally and selective EP3 receptor antagonist, with an IC50 of 1.9 nM. EP3 antagonist 6 can inhibits PGE2-induced (HY-101952) uterine contraction in pregnant rats.
    EP3 antagonist 6
  • HY-101236
    ICI 192605
    		Antagonist
    ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619.
    ICI 192605
  • HY-122558
    AM432 sodium
    		Antagonist
    AM432 (sodium) is a potent and selective antagonist of the DP2 receptor (CRTH2). AM432 (sodium) exhibits excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation. AM432 (sodium) also demonstrates excellent pharmacokinetics in dog and mouse models of inflammatory disease.
    AM432 sodium
  • HY-19078
    SQ-30741
    		Antagonist
    SQ-30741 is a thromboxane A2 receptor antagonist. SQ-30741 reduces vasoconstriction in a feline pulmonary vascular bed model. SQ-30741 increases relaxation of aortic endothelium and vascular smooth muscle in adult rats in a spontaneously hypertensive rat model. SQ-30741 can be used in research on cardiovascular diseases such as hypertension.
    SQ-30741
  • HY-116811
    AZ-11665362
    		Antagonist
    AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC50 of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases.
    AZ-11665362
  • HY-110351
    BGC-20-1531 hydrochloride
    		Antagonist
    BGC 20-1531 (PGN 1531) hydrochloride is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC 20-1531 hydrochloride has the potential for the research of migraine headache.
    BGC-20-1531 hydrochloride
  • HY-125150
    AL-3138
    		Antagonist
    AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production.
    AL-3138
  • HY-19189
    Terbogrel
    		Antagonist
    Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor, with both IC50s of about 10 nM.
    Terbogrel
  • HY-101602
    Aligeron
    		Antagonist
    Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
    Aligeron
  • HY-135773
    CRTh2 antagonist 3
    		Antagonist
    CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist. CRTh2 antagonist 3 enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd of 8.4 μM. CRTh2 antagonist 3 has the potential for cardiovascular inflammation.
    CRTh2 antagonist 3
  • HY-139119
    Prostaglandin F2α dimethyl amide
    		Antagonist
    Prostaglandin F2α dimethyl amide is an antagonist for Prostaglandin F2α (HY-12956), which blocks 50% contraction on gerbilMeriones unguiculatus colon induced by PGF2α at 3.2 μg/mL.
    Prostaglandin F2α dimethyl amide
  • HY-110198
    ONO-8130
    		Antagonist
    ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research.
    ONO-8130
  • HY-14466
    GW 848687X
    		Antagonist
    GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain.
    GW 848687X
  • HY-108561
    L-670596
    		Antagonist
    L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069.
    L-670596
  • HY-116099
    ER-819762
    		Antagonist
    ER-819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor. ER-819762 can be used for rheumatoid arthritis research.
    ER-819762
  • HY-121594
    GSK-269984B
    		Antagonist
    GSK-269984B is a potent EP1 antagonist. GSK-269984B has the potential for inflammatory pain research.
    GSK-269984B
  • HY-175077
    IP receptor antagonist 1
    		Antagonist
    CAY10449 is an I prostanoid receptor antagonist. CAY10449 can reverse iloprost-induced TEER reduction. CAY10449 can also reverse the effect of ONO-1301 in mouse model. CAY10449 can be studied in research on athsma and allergic airway inflammation.
    IP receptor antagonist 1
  • HY-163091
    EP4 receptor antagonist 5
    		Antagonist
    EP4 receptor antagonist 5 is a potent and selective prostanoid EP4 receptor antagonist that can reduce inflammation Freund’s adjuvant (CFA) model.
    EP4 receptor antagonist 5
  • HY-160844
    CT-133
    		Antagonist
    CT-133 is a selective and potent CRTH2 Receptor antagonist, with a Ki value of 2.2 nM. The Ki value for the DP1 receptor is greater than 3800 nM. CT-133 inhibits neutrophil migration induced by PGD2 (HY-101988). CT-133 significantly alleviates lung inflammation and improves lung function impairment in a mouse model of acute lung injury (ALI) induced by cigarette smoke. CT-133 effectively inhibits the excessive expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokines (KC), and reverses the inhibition of the anti-inflammatory factor IL-10. CT-133 can be used for the study of ALI.
    CT-133
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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